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Lactoferrin Rabbit anti-Bovine, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA140280

Catalog No. 01-676-399



Description

Description

PA1-40280 detects Lactoferrin from bovine samples. PA1-40280 has been successfully used in immunoprecipitation, ELISA, and Western blot applications. The PA1-40280 imunogen is bovine lactoferrin.

Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.
Specifications

Specifications

Lactoferrin
Polyclonal
Unconjugated
LTF
Liquid
LTF
Bovine lactoferrin.
Protein A
RUO
Antibody
Polyclonal
Bovine
ELISA, Immunoprecipitation, Western Blot
0.1 mg/mL
PBS with 0.1% BSA and 0.02% sodium azide
P24627
GIG12, HLF2, LF
Rabbit
IgG
100 μg
4° C
Primary
280846
Documents
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