Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Lamin A/C Mouse anti-Human, Mouse, Rat, Clone: Jol3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA15820

Catalog No. 01-674-927


Add to cart

Description

Description

MA1-5820 reacts with human dermal fibroblasts in immunocytochemistry. Other cell/tissue types have not been tested in this application. It reacts with human, mouse and rat samples in Western blot. This antibody recognizes the common tail domain of Lamin A+C, epitope aa 464-572.

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but domit genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
Specifications

Specifications

Lamin A/C
Monoclonal
Unconjugated
LMNA
Liquid
LMNA
Recombit bacterially expressed full length protein
1 mL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
16905, 4000, 60374
ChIP assay, Immunocytochemistry, Immunofluorescence, Western Blot
Jol3
tissue culture supernatant with 0.1% sodium azide
P02545, P48678, P48679
Prelamin-A/C, Lamin-A/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1
Mouse
IgG1
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit