Lamin A/C Mouse anti-Human, Mouse, Clone: Jol5, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA15821
MA1-5821 detects an un-phosphorylated form of lamin A/C and the epitope is mapped to the N-terminal head domain of both proteins (aa 1-171). It reacts with mouse myoblasts (C2C12) in Western blot applications. Other cell/tissue types have not been tested in Western blot. Detects a band of approximately 70 kDa (Lamin A) and 60kDa (Lamin C).Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but domit genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
|Recombit bacterially expressed full length protein|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|tissue culture supernatant with 0.1% sodium azide|
|Prelamin-A/C, Lamin-A/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1|
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