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Lamin C Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA15827

Catalog No. 01-674-977


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Description

Description

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.

PA1-5827 detects Lamin C in human, rat and mouse samples.PA1-5827 has been successfully used in immunofluorescence, Western blot and immunohistochemistry procedures. PA1-5827 reacts strongly in immunoblotting with fragments corresponding to peptide 319-572aa of Lamin C. When tested against nuclear protein extracts from HeLa cells it reacts with a single band migrating at 65 kDa.The PA1-5827 immunogen is a synthetic peptide corresponding to the N-terminal residues K-HHVSGSRR of human lamin C, coupled to KLH.
Specifications

Specifications

Lamin C
Polyclonal
PBS with 0.1% sodium azide
P02545, P48678, P48679
C type lamin
Rabbit
IgG
200 μL
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Primary
16905, 4000, 60374
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
LMNA
Liquid
LMNA
A peptide made from the last 8 amino acids of lamin C, including an N-terminal lysine as a linker (KHHVSGSRR), coupled to KLH
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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