anti-Laminin γ2 (Laminin 5), Clone: D4B5, Millipore™ (Chemicon™)

Manufacturer: EMD Millipore MAB19562DEL

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Catalog No. 50-174-998

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    Specifications

    Antigen Laminin γ2 (Laminin 5)
    Conjugate Unlabeled
    Cross Reactivity Human
    Format Semi-purified
    Host Species Mouse
    Immunogen Amino acid residues 382-608 of human laminin γ 2 chain (III domain) expressed as a GST fusion protein
    Isotype IgG1
    Quantity 100μg
    Regulatory Status RUO
    Research Discipline Cell Structure
    Primary or Secondary Primary
    Monoclonal or Polyclonal Monoclonal

    Laminins are basement membrane, extracellular matrix glycoproteins that are composed of alpha, beta and gamma heterotrimeric chains. Different combinations of five alpha chains, three beta chains, and two gamma chains form at least 12 laminin isoforms. Laminin-5 (LN5), which consists of laminin alpha3, beta3 and gamma2 chains, is a highly conserved component of anchoring filaments underlying the hemidesmosome structure of epidermal keratinocytes. Mutations or deletion in the LN5 genes (LAMA3, LAMB3, and LAMC2) is associated with epidermolysis bullosa, a lethal skin blistering disease. LN5 may stabilize the epidermal/dermal junction of skin through binding with integrins alpha3/beta1, alpha6/beta4 and type VII collagen and has a critical role in the anchorage and locomotion of a wide variety of cell types, including epithelial cells, fibroblasts, neurons and leukocytes. Compared to fibronectin, collagen, or vitronectin, cells of epithelial origin will adhere to Laminin-5 faster and will spread to a larger extent. Recently, Laminin-5 is attracting attention as a substrate for carcinoma cells that may stimulate migration, since it has been detected at the leading edge of invasive cancer tissue in several types of human carcinomas (Niki, et al., 2002, Lohi, et al., 2001).

    ELISA, Immunohistochemistry (Paraffin), Western Blotting

  • Description & Specifications

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