Laminin B2 Mouse, Unlabeled, Clone: 22, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610722
DescriptionThe basal lamina contains Collagen Type IV, proteoglycans, and glycoproteins. Laminin is a high molecular weight ( ∽850 kDa) oligomer, consisting of three different chains (A, B1, and B2) joined by disulfide bonds. The overall structure predicts two helical domains (I&II) at the COOH-terminal, cysteine-rich repeats (III&V), and two globular domains (IV&VI). Domains IV and VI are the binding sites for collagen and heparan sulfate, respectively. Several isoforms have been identified for the genes of each chain. Laminin B2 is 1576 amino acids plus a 33 amino acid signal peptide, 14 glycosylation sites, and 12 cysteine repeat domains. The expression of the Laminin subunits is detected rapidly during development and tissue regeneration. Attachment of cells to the basal lamina affects mitogenesis, motility, and differentiation.
|Human Laminin B2 aa. 506-691|
|Human, Rabbit, Rat|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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