Laminin gamma-1 Mouse anti-Human, Clone: M1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA519253
Peptide Sequence: MNKRRTSHRI WKNKLPEYMR RPKGPVTKLW RSMPAWLSLaminins are essential and abundant structural non-collagenous glycoproteins localizing to basement membranes. Basement membranes (cell-associated extracellular matrices (ECMs)) are polymers of Laminins with stabilizing Type IV Collagen networks, Nidogen and several proteoglycans. Basement membranes are found under epithelial layers, around the endothelium of blood vessels, and surrounding muscle, peripheral nerve and fat cells. Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression and tissue architecture. Each Laminin is a heterotrimer of alpha, beta and gamma chain subunits that undergoes cell-secretion and incorporation into the ECM. Laminins can self-assemble, bind to other matrix macromolecules and have unique and shared cell interactions mediated by Integrins, dystroglycan and cognate Laminin receptors. The human Laminin gamma-1 gene maps to chromosome 1q31 and is ubiquitously expressed in tissues that produce basement membranes.
|PBS with no preservative; pH 7.4|
|S-LAM beta, S-laminin subunit beta, laminin B1s chain, laminin S, laminin subunit beta-2, laminin-11 subunit beta, laminin-14 subunit beta, laminin-15 subunit beta, laminin-3 subunit beta, laminin-4 subunit beta, laminin-7 subunit beta, laminin-9 subunit beta|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Proximity Ligation Assay (PLA), Western Blot|
|LAMC1 (AAH15586, 1 a.a. ∽ 38 a.a) full-length recombit protein with GST tag. MW of the GST tag alone is 26 KDa.|
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