Laminin Rabbit anti-Mammalia, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA136119
This antibody can be used to detect laminin proteins in immunohistochemistry using frozen sections or standard formaldehyde-fixed paraffin-embedded tissues. For IHC (F), fixation with acetone for 5 min. at -20°C is recommended. For IHC (P), proteolytic treatment with pepsin is recommended. Before use, dilute immediately using PBS or Tris. Recommended positive control: skin or kidney tissue. Store undiluted antibody at 2-8°C for 2 months. For long-term storage, aliquote and store at -20°C, avoiding freeze/thaw cycles.Laminin is a non-collagenous protein of basement membranes. This glycoprotein has a molecular weight of about 900.000 dalton. By rotary shadowing it has a cross-like shape, consisting of one long arm, (400 kD) and three short arms (200 kD). Antibodies to laminin localize exclusively in basement membranes. Laminin is found throughout the basement membrane, but the reaction with the antibodies to Laminin is more intense in the lamina lucida, the part of the basement membrane adjacent to the cell membrane. Laminin binds to type IV collagen, a component exclusively localized in the basement membrane. Laminin has been shown to play a role in cell adhesion and attachment in vivo and in vitro.
|whole serum with no preservative|
|Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
|Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|16772, 284217, 316758|
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