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LAMTOR1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523086

Catalog No. PIPA523086


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Description

Description

The Ragulator complex is comprised of three proteins, C11orf59, ROBLD3, and MAPKSP1, which targets mTORC1 to lysosomal surfaces. This normal endosomal trafficking is taken advantage of by certain viruses, including coronavirus, which has increased replication when C11orf59 is interfered with. C11orf59 is positively regulated by cellular cholesterol depletion and negatively regulated by cellular cholesterol loading. It is involved in LDL uptake and cholesterol homeostasis. C11orf59 and PPAR-alpha work together to control lipid and carbohydrate metabolism in diabetes. Nearly all effects of C11orf59 are associated with mTORC1 kinase growth promotion, and disregulation of the normal mTOR pathway.
Specifications

Specifications

LAMTOR1
Polyclonal
Unconjugated
LAMTOR1
Liquid
LAMTOR1
A synthetic peptide made to an C-terminal region of the human c11orf59 protein (within residues 50-250).
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.2 mg/mL
PBS with 0.1% BSA, 50% glycerol and 0.05% sodium azide
Q6IAA8, Q9CQ22, Q6P791
PP7157, C11orf59, PDRO, Ragulator1, p18, p27RF-Rho, RhoA activator C11orf59, late endosomal/lysosomal adaptor and MAPK and MTOR activator 1, lipid raft adaptor protein p18, p27Kip1-releasing factor from RhoA, p27kip1 releasing factor from RhoA, protein associated with DRMs and endosomes, ragulator complex protein LAMTOR1, ragulator complex protein PDRO
Rabbit
IgG
50 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
308869, 55004, 66508
Documents
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