LAMTOR1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523086
The target sequence has 98% sequence homology with bovine.The Ragulator complex is comprised of three proteins, C11orf59, ROBLD3, and MAPKSP1, which targets mTORC1 to lysosomal surfaces. This normal endosomal trafficking is taken advantage of by certain viruses, including coronavirus, which has increased replication when C11orf59 is interfered with. C11orf59 is positively regulated by cellular cholesterol depletion and negatively regulated by cellular cholesterol loading. It is involved in LDL uptake and cholesterol homeostasis. C11orf59 and PPAR-alpha work together to control lipid and carbohydrate metabolism in diabetes. Nearly all effects of C11orf59 are associated with mTORC1 kinase growth promotion, and disregulation of the normal mTOR pathway.
|A synthetic peptide made to an C-terminal region of the human c11orf59 protein (within residues 50-250).|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.1% BSA, 50% glycerol and 0.05% sodium azide|
|Q6IAA8, Q9CQ22, Q6P791|
|PP7157, C11orf59, PDRO, Ragulator1, p18, p27RF-Rho, RhoA activator C11orf59, late endosomal/lysosomal adaptor and MAPK and MTOR activator 1, lipid raft adaptor protein p18, p27Kip1-releasing factor from RhoA, p27kip1 releasing factor from RhoA, protein associated with DRMs and endosomes, ragulator complex protein LAMTOR1, ragulator complex protein PDRO|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|308869, 55004, 66508|
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