LAP2 alpha Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA15828
PA1-5828 detects LAP2 alpha in human, rat and mouse samples. PA1-5828 has been successfully used in Western blot and immunofluorescence procedures. The PA1-5828 immunogen is recombit LAP2a C terminus (188-693).In eukaryotic cells, the nuclear envelope consists of inner and outer membranes which define the border between the nucleus and cytoplasm. The inner and outer nuclear membranes are joined by large, supramolecular assemblies called nuclear pore complexes through which various molecules pass into and out of the nucleus. The inner membrane is lined by a filamentous meshwork called the nuclear lamina made up of proteins called lamins. The attachment of the lamins to the inner nuclear membrane appears to occur through their association with 4 related integral membrane proteins called Lamin Associated Polypeptides (LAPs). LAP 1A, 1B and 1C share a high degree of sequence homology while LAP 2 is distinct from the others. LAP 1A/B bind lamins A, C and B1, while LAP 2 binds lamin B1 only. In addition to lamin binding, LAP 2 has been shown to bind to chromosomes. Phosphorylation of LAP 2 during mitosis inhibits binding to both lamins and chromosomes suggesting that LAP 2 plays an important role in nuclear envelope re-assembly.
|whole serum diluted in PBS with 0.09% sodium azide|
|P42166, Q61029, Q62733|
|lamin associated protein 2|
|Human, Mouse, Rat|
|ChIP assay, Immunocytochemistry, Immunofluorescence, Western Blot|
|Recombit His-tagged human LAP2 C terminus. (aa 188-693).|
|-20° C, Avoid Freeze/Thaw Cycles|
|21917, 25359, 7112|
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