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Lass5 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520569

Catalog No. PIPA520569


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Description

Description

A suggested positive control is SK-N-SH cell lysate. PA5-20569 can be used with blocking peptide PEP-0689.

The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predomit ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis.
Specifications

Specifications

LASS5
Polyclonal
Unconjugated
CERS5
Liquid
CERS5
A 17 amino acid peptide near the carboxy terminus of the human LASS5.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q8N5B7, Q9D6K9
LASS5, Trh4; LAG1 homolog, ceramide synthase 5; LAG1 longevity assurance homolog 5
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
366984, 71949, 91012
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