LAT, clone: LAT-1D1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119396
LAT (Linker for Activation of T cells) is a 36-38kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.This antibody will not cross-react with human.A suggested positive control for this product is mouse spleen.
|PBS with 15mM sodium azide; pH 7.4|
|Linker for activation of T cells, pp36|
|4° C, do not freeze|
|Immunocytochemistry, Immunoprecipitation, Western Blot|
|Bacterially expressed full-length rat LAT|
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