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LAT, clone: LAT-1D1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119396

Catalog No. 01-676-144

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

LAT (Linker for Activation of T cells) is a 36-38kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.

This antibody will not cross-react with human.A suggested positive control for this product is mouse spleen.
Specifications

Specifications

LAT
Monoclonal
1mg/mL
PBS with 15mM sodium azide; pH 7.4
O54957, O70601
Linker for activation of T cells, pp36
Murine
IgG2a
100μg
4° C, do not freeze
Primary
16797, 81511
Immunocytochemistry, Immunoprecipitation, Western Blot
LAT-1D1
Unconjugated
Lat
Liquid
LAT
Bacterially expressed full-length rat LAT
Protein A
RUO
Antibody
Monoclonal
Murine, Rat
Documents
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