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LBP Mouse anti-Bovine, Canine, Goat, Human, Non-human primate, Ovine, Porcine, Rabbit, Rat, Clone: 6G3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA140129

Catalog No. 01-676-520


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Description

Description

MA1-40129 detects LBP from human, bovine, dog, goat, cynomologous monkey, rabbit, rat, sheep, and swine samples. Does not react with mouse or equine samples. MA1-40129 has been successfully used in immunoprecipitation, functional assays and ELISA applications. Not useful in Immunohistochemistry or Western blot applications. ELISA: monoclonal antibody 3F9 can be used both as coating and as detector. The MA1-40129 immunogen is human natural and recombit LBP. Endotoxin <24 EU/mg.

LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. LBP strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.
Specifications

Specifications

LBP
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA and no preservative
Q2TBI0, P18428, Q63313
lipopolysaccharide binding protein
Mouse
IgG1
100 μg
4° C
Primary
100009124, 101104595, 102186029, 29469, 3929, 397303, 485869, 512242
ELISA, Functional Assay, Immunoprecipitation
6G3
Unconjugated
LBP
Liquid
LBP
Human natural and recombit LBP.
Protein G
RUO
Antibody
Monoclonal
Bovine, Canine, Goat, Human, Non-human Primate, Ovine, Porcine, Rabbit, Rat
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