Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

LBP Rat anti-Mouse, Clone: RR433-8, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA140030

Catalog No. 01-676-488


Add to cart

Description

Description

Endotoxin level < 24 EU/mg. This antibody reacts highly specific with mouse natural and recombit LBP. The antibody is a type II antibody blocking the LPS binding to CD14. The MA1-40030 immunogen is mouse natural and recombit LBP. MA1-40030 detects LBP from mouse samples. MA1-40030 has been successfully used in ELISA, Functional Assays and Western blot applications.

LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. LBP strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.
Specifications

Specifications

LBP
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA
Q61805
Lipopolysaccharide binding protein
Rat
IgG2a
100 μg
4° C
Primary
16803
ELISA, Functional Assay, Western Blot
RR433-8
Unconjugated
Lbp
Liquid
LBP
Murine natural and recombit LBP.
Protein G
RUO
Antibody
Monoclonal
Mouse
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit