LBP Rat anti-Mouse, Clone: RR433-8, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA140030
Endotoxin level < 24 EU/mg. This antibody reacts highly specific with mouse natural and recombit LBP. The antibody is a type II antibody blocking the LPS binding to CD14. The MA1-40030 immunogen is mouse natural and recombit LBP. MA1-40030 detects LBP from mouse samples. MA1-40030 has been successfully used in ELISA, Functional Assays and Western blot applications.LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. LBP strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.
|PBS with 0.1% BSA|
|Lipopolysaccharide binding protein|
|ELISA, Functional Assay, Western Blot|
|Murine natural and recombit LBP.|
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