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LC3A/LC3B Rabbit anti-Canine, Human, Mouse, Rat, Zebrafish, Biotin, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA522729

Catalog No. PIPA522729


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Description

Description

The target sequence has 100% sequence homology with xenopus, bovine and zebrafish.

Autophagy is a process of intracellular bulk degradation in which cytoplasmic components, including organelles, are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. During macroautophagy, the sequestering vesicles, termed autophagosomes, fuse with the lysosome or vacuole resulting in the delivery of an inner vesicle (autophagic body) into the lumen of the degradative compartment. There are 16 proteins participating in the autophagy pathway in human. The autophagy protein LC3, a mammalian homologue of Atg8, was originally identified as microtubule-associated protein 1 light chain 3. It is a component of both the MAP1A and MAP1B microtubule-binding domains and the heavy-chain independent regulation of LC3 expression might modify MAP1 microtubule-binding activity during development. LC3 is the only known mammalian protein identified that stably associates with the autophagosome membranes. LC3-I is cytosolic and LC3-II is membrane bound and enriched in the autophagic vacuole fraction. The detection of LC3-I to LC3-II conversion is a useful and sensitive marker for distinguishing autophagy in mammalian cells.
Specifications

Specifications

LC3A/LC3B
Polyclonal
Biotin
MAP1LC3B
Liquid
MAP1LC3A, MAP1LC3B
A synthetic peptide made to an internal portion of the human LC3 protein sequence (between residues 25-121).
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Canine, Human, Mouse, Rat, Zebrafish
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
0.9 mg/mL
PBS with 0.05% sodium azide
Q9GZQ8, Q9H492, Q91VR7, Q9CQV6, Q62625, Q6XVN8
Map1lc3a, MAP1LC3B, LC3, MAP1LC3A, MAP1LC3B, MAP1LC3, Microtubule-associated proteins 1A/1B light chain, MAP1A/MAP1B LC3, MAP1 light chain 3-like protein 2, MAP1 light chain 3-like protein 1, Microtubule-associated proteins 1A/1B light chain 3B
Rabbit
IgG
100 μL
4° C, store in dark
Primary
322425, 362245, 406466, 477201, 479619, 64862, 66734, 67443, 81631, 84557
Documents
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