Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

LC3A Rabbit anti-Bovine, Human, Mouse, Rat, Zebrafish, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA522990

Catalog No. PIPA522990


Add to cart

Description

Description

In ICC/IF, autophagosome formation has been seen in HeLa cells after treatment with 50uM chloroquine. Suggested positive control: human brain lysate, LC3 overexpression lysate.

LC3, a mammalian homologue of Apg8, was originally identified as microtubule-associated protein 1 light chain 3. It is a component of both the MAP1A and MAP1B microtubule-binding domains and the heavy-chain independent regulation of LC3 expression might modify MAP1 microtubule-binding activity during development. However, LC3 is now thought to also be involved in autophagy. LC3-I is cytosolic and LC3-II is membrane bound and enriched in the autophagic vacuole fraction. LC3-II is the first mammalian protein identified that specifically associates with the autophagosome membranes.
Specifications

Specifications

LC3A
Polyclonal
Unconjugated
MAP1LC3A
Liquid
MAP1LC3A
Genomic sequence made to a N-terminal portion of the human LC3A protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Human, Mouse, Rat, Zebrafish
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
0.2 mg/mL
PBS with 0.1% BSA, 50% glycerol and 0.05% sodium azide
Q2HJ23, Q9H492, Q91VR7, Q6XVN8
RP11-346K17.1, ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3, MAP1 light chain 3-like protein 1, MAP1A/1B light chain 3 A, MAP1A/MAP1B LC3 A, MAP1A/MAP1B light chain 3 A, autophagy-related protein LC3 A, autophagy-related ubiquitin-like modifier LC3 A, microtubule-associated proteins 1A/1B light chain 3, microtubule-associated proteins 1A/1B light chain 3A
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
362245, 406466, 514547, 66734, 84557
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit