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LC3A Rabbit anti-Bovine, Human, Mouse, Rat, Zebrafish, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA522990
In ICC/IF, autophagosome formation has been seen in HeLa cells after treatment with 50uM chloroquine. Suggested positive control: human brain lysate, LC3 overexpression lysate.LC3, a mammalian homologue of Apg8, was originally identified as microtubule-associated protein 1 light chain 3. It is a component of both the MAP1A and MAP1B microtubule-binding domains and the heavy-chain independent regulation of LC3 expression might modify MAP1 microtubule-binding activity during development. However, LC3 is now thought to also be involved in autophagy. LC3-I is cytosolic and LC3-II is membrane bound and enriched in the autophagic vacuole fraction. LC3-II is the first mammalian protein identified that specifically associates with the autophagosome membranes.
|Genomic sequence made to a N-terminal portion of the human LC3A protein.|
|Antigen affinity chromatography|
|Bovine, Human, Mouse, Rat, Zebrafish|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
|PBS with 0.1% BSA, 50% glycerol and 0.05% sodium azide|
|Q2HJ23, Q9H492, Q91VR7, Q6XVN8|
|RP11-346K17.1, ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3, MAP1 light chain 3-like protein 1, MAP1A/1B light chain 3 A, MAP1A/MAP1B LC3 A, MAP1A/MAP1B light chain 3 A, autophagy-related protein LC3 A, autophagy-related ubiquitin-like modifier LC3 A, microtubule-associated proteins 1A/1B light chain 3, microtubule-associated proteins 1A/1B light chain 3A|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|362245, 406466, 514547, 66734, 84557|
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