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LC3B Rabbit anti-Bovine, Canine, Human, Mouse, Non-human primate, Porcine, Rat, Zebrafish, Biotin, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA522936

Catalog No. PIPA522936


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Description

Description

LC3B (Autophagy Marker Light Chain 3B, MAP1A/MAP1B LC3 B) in humans, is encoded by the gene MAP1LC3B (Microtubule-associated proteins 1A/1B light chain 3B). LC3B is associated with microtubule assembly and important is in neurogenesis. Recent studies indicate that LC3B plays a vital role in autophagy, a process that involves the bulk degradation of cytoplasmic component. Three human LC3 isoforms undergo post-translational modifications during autophagy. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). LC3B is a microtubule-associated protein that mediate the physical interactions between microtubules and components of the cytoskeleton. LC3B may play a role in processes involving cancer, aging, metabolic and neurodegenerative disorders and cardiovascular/pulmonary diseases.
Specifications

Specifications

LC3B
Polyclonal
Biotin
MAP1LC3B
Liquid
MAP1LC3B
A synthetic peptide made to the N-terminal region of the human LC3, isoform B protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Canine, Human, Mouse, Non-human primate, Porcine, Rat, Zebrafish
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
0.85 mg/mL
PBS with 0.05% sodium azide
O41515, Q9GZQ8, Q9CQV6, Q62625
ATG8F, LC3B, MAP1A/1BLC3, MAP1 light chain 3-like protein 2, MAP1A/MAP1B LC3 B, MAP1A/MAP1B light chain 3 B, autophagy-related ubiquitin-like modifier LC3 B, microtubule-associated proteins 1A/1B light chain 3B
Rabbit
IgG
100 μL
4° C, store in dark
Primary
100462754, 322425, 408001, 479619, 64862, 67443, 81631
Documents
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