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LDLR Mouse anti-Human, Clone: 472413, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523916

Catalog No. PIMA523916


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Description

Description

In direct ELISAs and Western blots, no cross-reactivity with recombit mouse (rm) LDL R, recombit human LRP-5, or rmLRP-6 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis (1). Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits (2). It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by LDL receptors on cultured cells (3).
Specifications

Specifications

LDLR
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P01130
FH, FHC, LDLCQ2, LDL receptor, low-density lipoprotein receptor, low-density lipoprotein receptor class A domain-containing protein 3
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3949
ELISA, Flow Cytometry, Immunoprecipitation, Western Blot
472413
Unconjugated
LDLR
Lyophilized
LDLR
CHO-derived recombit human LDL R Ala22-Arg788
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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