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LDLR Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA522976

Catalog No. PIPA522976


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Description

Description

This antibody is predicted to react with monkey based on 100% sequence homology. This antibody has 92% sequence homology with mouse.

The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis (1). Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits (2). It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by LDL receptors on cultured cells (3).
Specifications

Specifications

LDLR
Polyclonal
Unconjugated
LDLR
Liquid
LDLR
Synthetic peptide made to an internal portion of the human protein (within residues 500-550).
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1.5 mg/mL
PBS with 0.1% sodium azide
P01130, P35951
FH, FHC, LDLCQ2, LDL receptor, low-density lipoprotein receptor, low-density lipoprotein receptor class A domain-containing protein 3
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
16835, 3949
Documents
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