LDLR Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA522976
This antibody is predicted to react with monkey based on 100% sequence homology. This antibody has 92% sequence homology with mouse.The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis (1). Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits (2). It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by LDL receptors on cultured cells (3).
|Synthetic peptide made to an internal portion of the human protein (within residues 500-550).|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.1% sodium azide|
|FH, FHC, LDLCQ2, LDL receptor, low-density lipoprotein receptor, low-density lipoprotein receptor class A domain-containing protein 3|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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