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LTK Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141118

Catalog No. 01-675-701


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Description

Description

Suggested positive control: K562 whole cell lysate.

Leukocyte tyrosine kinase (LTK) is a receptor-type protein tyrosine kinase, belonging to the insulin receptor superfamily, and is mainly expressed in B lymphocyte precursors and neuronal tissues.  LTK utilizes insulin receptor substrate-1 (IRS-1) and Shc as major two substrates and possesses two NPXY motifs for them separately, tyrosine 485 of one NPXY motif at the juxtamembrane domain for IRS-1 and tyrosine 862 of another NPXY motif at the carboxyl-terminal domain for Shc. It has also been shown that p85 subunit of PI3 kinase directly binds to tyrosine 753 of LTK, which is located within a YXXM motif. Tyrosine 485 and 753 are responsible for IRS-1 and PI3K mediated survival effects of LTK, respectively.
Specifications

Specifications

LTK
Polyclonal
Unconjugated
LTK
Liquid
LTK
Synthetic peptide corresponding to residues 800-864 of human LTK.
Protein G
RUO
Antibody
Polyclonal
Human
Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
P29376
LTK
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
4058
Documents
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