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LFG Mouse anti-Human, Clone: 2C2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA521391

Catalog No. PIMA521391


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Description

Description

Peptide Sequence: MTQGKLSVAN KAPGTEGQQQ VHGEKKEAPA VPSAPPSYEE ATSGEGMKAG AFPPAPTAVP LHPSWAYVDP SSSSSYDNGF PTGDHELFTT FSWDDQKVRR VFVRKVYTIL LIQLLVTLAV VALFTFCDPV KDYVQANPGW YWASYAVFFA TYLTLACCSG PRRHFPWNLI LLTVFTLSMA YLTGMLSSYY NTTSVLLCLG ITALVCLSVT VFSFQTKFDF TSCQGVLFVL LMTLFFSGLI LAILLPFQYV PWLHAVYAAL GAGVFTLFLA LDTQLLMGNR RHSLSPEEYI FGALNIYLDI IYIFTFFLQL FGTNRE

LFG, a seven transmembrane spanning protein, is a recently identified member of a family whose members can inhibit apoptotic cell death induced by Fas receptor. LFG is a human homolog of rat NMP35 and consists of a conserved transmembrane domain and a small cytoplasmic domain. Reports have shown that LFG protects the cell from Fas-mediated neuronal cell death in a novel way. LFG binds to Fas receptor but doesn ft.t have any effect in reducing Fas expression or decreasing the ability of FADD binding to the receptor. Furthermore, LFG doesn ft.t protect the cells from TNF-alpha mediated cell death process. Although LFG is ubiquitously expressed, Northern blot analysis detected an increased expression in hippocampus and other neural tissues, suggesting a protective role in neurodegenerative diseases.
Specifications

Specifications

LFG
Monoclonal
1 mg/mL
PBS with no preservative; pH 7.4
Q9BWQ8
LFG, LFG2, NGP35, NMP35, TMBIM2; fas apoptotic inhibitory molecule 2; neural membrane protein 35; protein lifeguard; transmembrane BAX inhibitor motif-containing protein 2
Mouse
IgG2a, kappa
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
23017
ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
2C2
Unconjugated
FAIM2
Liquid
FAIM2
FAIM2 (AAH00051, 1 a.a. ∽ 316 a.a) full-length recombit protein with GST tag. MW of the GST tag alone is 26 KDa.
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Documents
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