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LGI1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520491

Catalog No. PIPA520491


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Description

Description

A suggested positive control is Hela cell lysate. PA5-20491 can be used with blocking peptide PEP-0611.

The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodomit lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predomit auditory symptoms. Two isoforms of LGI1 are known to exist; this LGI1 antibody will recognize only the longer form.
Specifications

Specifications

LGI1
Polyclonal
Unconjugated
LGI1
Liquid
LGI1
A 14 amino acid peptide from near the center of human LGI1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
O95970, Q9JIA1, Q8K4Y5
UNQ775/PRO1569, EPITEMPIN, EPT, ETL1, IB1099; epitempin-1; leucine-rich glioma-inactivated protein 1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
252892, 56839, 9211
Documents
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