LGI4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520514
A suggested positive control is rat brain tissue lysate. PA5-20514 can be used with blocking peptide PEP-0634.The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodomit lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predomit auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development.
|A 17 amino acid peptide from near the carboxy terminus of human LGI4.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|PBS with 0.02% sodium azide|
|UNQ6515/PRO21485, LGIL3; LGI1-like protein 3; leucine-rich glioma-inactivated gene 4; leucine-rich glioma-inactivated protein 4; leucine-rich repeat LGI family member 4|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|163175, 243914, 361549|
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