LGP2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520435
A suggested positive control is rat kidney tissue lysate. PA5-20435 can be used with blocking peptide PEP-0552.Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.
|a 11 amino acid peptide from near the center of human LGP2.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|PBS with 0.02% sodium azide|
|D11LGP2, D11lgp2e, LGP2; RIG-I-like receptor LGP2; RLR; RNA helicase LGP2; ortholog of mouse D11lgp2; probable ATP-dependent RNA helicase DHX58; probable ATP-dependent helicase LGP2; protein D11Lgp2 homolog|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|303538, 79132, 80861|
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