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LFG Rabbit anti-Canine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141589

Catalog No. 01-675-208


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Description

Description

LFG, a seven transmembrane spanning protein, is a recently identified member of a family whose members can inhibit apoptotic cell death induced by Fas receptor. LFG is a human homolog of rat NMP35 and consists of a conserved transmembrane domain and a small cytoplasmic domain. Reports have shown that LFG protects the cell from Fas-mediated neuronal cell death in a novel way. LFG binds to Fas receptor but doesn’t have any effect in reducing Fas expression or decreasing the ability of FADD binding to the receptor. Furthermore, LFG doesn’t protect the cells from TNF-alpha mediated cell death process. Although LFG is ubiquitously expressed, Northern blot analysis detected an increased expression in hippocampus and other neural tissues, suggesting a protective role in neurodegenerative diseases.
Specifications

Specifications

LFG
Polyclonal
Unconjugated
FAIM2
Liquid
FAIM2
Synthetic peptide corresponding to residues 1-50 of human Lifeguard.
Protein G
RUO
Antibody
Polyclonal
Canine, Human, Mouse, Non-human primate, Rat
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
1.0 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
Q9BWQ8, Q8K097, O88407
Faim2
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
23017, 246274, 477613, 72393
Documents
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