LFG Rabbit anti-Canine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141589
DescriptionLFG, a seven transmembrane spanning protein, is a recently identified member of a family whose members can inhibit apoptotic cell death induced by Fas receptor. LFG is a human homolog of rat NMP35 and consists of a conserved transmembrane domain and a small cytoplasmic domain. Reports have shown that LFG protects the cell from Fas-mediated neuronal cell death in a novel way. LFG binds to Fas receptor but doesn’t have any effect in reducing Fas expression or decreasing the ability of FADD binding to the receptor. Furthermore, LFG doesn’t protect the cells from TNF-alpha mediated cell death process. Although LFG is ubiquitously expressed, Northern blot analysis detected an increased expression in hippocampus and other neural tissues, suggesting a protective role in neurodegenerative diseases.
|Synthetic peptide corresponding to residues 1-50 of human Lifeguard.|
|Canine, Human, Mouse, Non-human primate, Rat|
|Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.2% gelatin and 0.05% sodium azide|
|Q9BWQ8, Q8K097, O88407|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|23017, 246274, 477613, 72393|
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