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LIME Rabbit anti-Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA119374

Catalog No. 01-676-747


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Description

Description

This antibody reacts with the cytoplasmic domain of LIME, and will not cross-react with human.

LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.
Specifications

Specifications

LIME
Polyclonal
PBS with 15mM sodium azide; pH 7.4
Q9EQR5
Lck-interacting molecule, Lime1
Rabbit
IgG
100 μg
4° C, do not freeze
Primary
72699
Immunoprecipitation, Western Blot
Unconjugated
Lime1
Liquid
LIME1
Bacterially expressed recombit fragment (amino acids 86-202) of mouse LIME with C-terminal His-tag
Protein A
RUO
Antibody
Polyclonal
Mouse
Documents
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