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LIME Mouse anti-Human, Clone: LIME-10, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119367

Catalog No. 01-676-123


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Description

Description

LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.
Specifications

Specifications

LIME
Monoclonal
Unconjugated
LIME1
Liquid
LIME1
COOH-terminal peptide comprising residues 281-296 of the human LIME conjugated to keyhole limpet hemocyanin
Purified
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Western Blot
LIME-10
PBS with 15mM sodium azide; pH 7.4
Q9H400
Lck-interacting molecule, Lime1
Mouse
IgG2a
100 μg
4° C, do not freeze
Primary
54923
Documents
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