LIME Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA119376
This antibody reacts with the cytoplasmic domain of LIME, and will not cross-react with mouse.LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.
|PBS with 15mM sodium azide; pH 7.4|
|Lck-interacting molecule, Lime1|
|4° C, do not freeze|
|Immunohistochemistry (Paraffin), Western Blot|
|Bacterially expressed intracellular fragment corresponding to aa 141-295 of human LIME|
|Ammonium sulfate precipitation|
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