Lin-28 Mouse anti-Human, Alexa Fluor 488, Clone: 6D1F9, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 563597
Lin-28 is an evolutionarily conserved RNA-binding protein that is expressed in embryonic tissue, embryonic stem cells, and some adult tissues (e.g. cardiac and skeletal muscle). Within these cells, it is localized to ribosomes, P-bodies, and stress granules. During embryonic development, Lin-28 acts as a “translational enhancer” by binding to certain mRNAs and increasing their translation efficiency. Additionally, Lin-28 is overexpressed in some human cancer cell lines and is associated with the malignant transformation of cells as well as advanced human malignancies. This role is thought to be tied to the binding of Lin-28 to pre-microRNA of let-7, which in its mature form promotes terminal differentiation of stem cells and suppresses tumors. The binding of Lin-28 to the immature version of let-7 blocks its cleavage into mature microRNA, thereby preventing it from carrying out its function in tumor suppression. Lin-28, in combination with additional factors, has been used to reprogram human somatic cells into induced pluripotent stem cells.
|Lin-28A, LIN28A, CSDD1, LIN28, ZCCHC1|
|Human Lin-28 Recombinant Protein|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Alexa Fluor 488|
|Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.|
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