LIN28A Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520898
A suggested positive control is Raji cell lysate. PA5-20898 can be used with blocking peptide PEP-1012.Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.
|A 15 amino acid peptide near the carboxy terminus of human Lin28.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A; RNA-binding protein LIN-28; protein lin-28 homolog A; zinc finger CCHC domain-containing protein 1; zinc finger, CCHC domain containing 1|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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