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LIN28A Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520898

Catalog No. PIPA520898


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Description

Description

A suggested positive control is Raji cell lysate. PA5-20898 can be used with blocking peptide PEP-1012.

Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.
Specifications

Specifications

LIN28A
Polyclonal
Unconjugated
LIN28A
Liquid
LIN28A
A 15 amino acid peptide near the carboxy terminus of human Lin28.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9H9Z2
CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A; RNA-binding protein LIN-28; protein lin-28 homolog A; zinc finger CCHC domain-containing protein 1; zinc finger, CCHC domain containing 1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
79727
Documents
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