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LIN7A Mouse anti-Human, Clone: P377, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA518298

Catalog No. PIMA518298


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Description

Description

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
Specifications

Specifications

LIN7A
Monoclonal
1 mg/mL
PBS with no preservative
O14910
VELI1, TIP-33, LIN-7A, lin-7 homolog A C. elegans, LIN7, MALS-1
Mouse
IgG2b
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
8825
Immunocytochemistry, Immunofluorescence, Western Blot
P377
Unconjugated
LIN7A
Liquid
LIN7A
Recombit fragment corresponding to a region within amino acids 12 and 227 of LIN7A
Protein G
RUO
Antibody
Monoclonal
Human
Documents
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