LIPA Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523080
The target sequence has 82% sequence homology with porcine and 73% sequence homology with rat and bovine.Lipase A is a critical enzyme for metabolism, sequestration and degradation of cholesterol. When LIPA is not effective in liver and kidney cells, lipoprotein cholesterol accumulates and leads to atherosclerosis, inflammation, Type 2 diabetes, and chronic kidney disease. In Wolman disease, deficiency of LIPA causes buildup of cholesterol in spleen, liver, bone marrow, intestine, adrenal glands and lymph nodes, which eventually causes such toxicity in children affected that they rarely live past 1 year of age. Intracellularly, LIPA mediates the uptake of cholesterol by the endosomal/lysosomal compartment, and hydrolyzes cholesterol esterases.
|A synthetic peptide made to an internal region of the human Lysosomal acid lipase protein (within residues 150-300).|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.1% BSA, 50% glycerol and 0.05% sodium azide|
|RP11-341B24.1, CESD, LAL, acid cholesteryl ester hydrolase, cholesterol ester hydrolase, cholesteryl esterase, lysosomal acid lipase, lysosomal acid lipase/cholesteryl ester hydrolase, sterol esterase|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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