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LKB1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520325

Catalog No. PIPA520325


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Description

Description

Despite the predicted molecular weight, LKB1 often migrates at a higher molecular weight in SDS-PAGE. A suggested positive control is PC-3 cell lysate. PA5-20325 can be used with blocking peptide PEP-0445.

LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11), a member of the serine/threonine kinase family, is a tumor suppressor. LKB1 physically associates with p53 and regulates specific p53 dependent apoptosis pathways. LKB1 is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK. Mutations in LKB1 gene are associated with Peutz Jeghers syndrome.
Specifications

Specifications

LKB1
Polyclonal
Unconjugated
STK11
Liquid
STK11
A 15 amino acid peptide from near the carboxy terminus of human LKB1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q15831, Q9WTK7
LKB1, PJS, hLKB1; liver kinase B1; polarization-related protein LKB1; renal carcinoma antigen NY-REN-19; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; serine/threonine-protein kinase STK11
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
20869, 6794
Documents
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