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LOX Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523002

Catalog No. PIPA523002


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Description

Description

This is a highly glycosylated protein and can exhibit bands at ~32 kDa, ~50 kDa and ~58 kDa representing the mature (secreted) form, the pro form and the glycosylated forms, respectively.

Lysyl oxidase (LOX) is an extracellular enzyme that is critical for the normal biosynthesis of collagens and elastin. LOX is synthesized as a 50 kDa precursor, secreted into the extracellular matrix and subsequently proteolytically processed to a 30 kDa active enzyme and an 18 kDa propeptide. LOX also reverts ras-mediated transformation and its expression is down-regulated in human cancers. Most recently, the lysyl oxidase pro-peptide (LOPP) has been associated with tumor suppression, as it inhibits ras-dependent cellular transformation.
Specifications

Specifications

LOX
Polyclonal
Unconjugated
LOX
Liquid
LOX
Synthetic peptide made to an internal portion of the human protein (within residues 118-168.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
1 mg/mL
PBS with 30% glycerol and 0.1% sodium azide
P28300, P16636
protein-lysine 6-oxidase
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
24914, 4015
Documents
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