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LPIN1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA116997

Catalog No. PIPA116997


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Description

Description

Suggested positive control: 3T3-L1 cell lysates, antigen standard for LPIN1 (transient overexpression lysate).

The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1&No.225; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPAR&No.225;. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
Specifications

Specifications

LPIN1
Polyclonal
Unconjugated
LPIN1
Liquid
LPIN1
Synthetic internal peptide corresponding to an internal region (within residues 300-400) of human LPIN1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry (Paraffin), Western Blot
0.8 mg/mL
PBS with 30% glycerol and 0.1% sodium azide
Q14693, Q91ZP3
LPIN1 , lipin 1 , DKFZp781P1796 , KIAA0188 , lipin-1
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
14245, 23175, 313977
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