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LRP5 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA513144

Catalog No. PIPA513144


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Description

Description

Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, protease clearance, and cell migration. Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes. All LRPs are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family.
Specifications

Specifications

LRP5
Polyclonal
PBS with 0.09% sodium azide
O75197, Q91VN0
Low-density lipoprotein receptor-related protein 5; LRP7
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
16973, 4041
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
LRP5
Liquid
LRP5
KLH conjugated synthetic peptide between 1538-1567 amino acids from the C-terminal region of human LRP5
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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