LRP6 Rat anti-Mouse, Clone: 290913, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA523995
In direct ELISAs, this antibody shows approximately 50-60% cross-reactivity with recombit human (rh) LRP-6 and no cross-reactivity with rhLDL R. Reconstitute at 0.5 mg/mL in sterile PBS.This gene encodes a member of the low density lipoprotein receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- processing but the precise locations of the cleavage sites have not been determined.
|PBS with 5% trehalose and No Preservative|
|LRP6, low density lipoprotein receptor-related protein 6, low density lipoprotein-related protein 6, ADCAD2, FLJ90062, FLJ90421, lpr6|
|-20° C, Avoid Freeze/Thaw Cycles|
|CHO-derived recombit mouse LRP-6 Met1-Pro1368|
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