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LRRFIP2 Rabbit anti-Equine, Human, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523458

Catalog No. PIPA523458


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Description

Description

Leucine-rich repeat flightless-interacting protein 2 (LRRFIP2) belongs to the LRRFIP family. LRRFIP2 has multifaceted functions in innate immunity, apoptosis and development. LRRFIP2 can bind to MyD88 and positively regulate TLR activity as measured by NF-kB activity and cytokine production in macrophages. LPS stimulation also increases LRRFIP2 expression in macrophages. By interacting with Dvl, LRRFIP2 increases the cellular levels of ß-catenin and activate ß-catenin/LEF/TCF-dependent transcriptional activity. A domit negative form of LRRFIP2 suppresses ectopic Wnt signaling in Xenopus embryos and partially inhibits endogenous dorsal axis formation. LRRFIP2 also interacts with Caspase-11 through Flightless-I protein and may be involved in the regulation of proinflammatory caspases by selectively modulating intracellular localization and caspase activity.
Specifications

Specifications

LRRFIP2
Polyclonal
Unconjugated
LRRFIP2
Liquid
LRRFIP2
Synthetic peptide (FDQRNYSSLRHSKPTSA (aa151-167)) of LRRFIP2 protein.
Protein A
RUO
Antibody
Polyclonal
Equine, Human, Non-human Primate
Immunohistochemistry (Paraffin)
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q9Y608
HUFI-2, LRR FLII-interacting protein 2, leucine-rich repeat flightless-interacting protein 2
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100050285, 9209
Documents
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