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LRRFIP2 Rabbit anti-Equine, Human, Non-human primate, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523458
DescriptionLeucine-rich repeat flightless-interacting protein 2 (LRRFIP2) belongs to the LRRFIP family. LRRFIP2 has multifaceted functions in innate immunity, apoptosis and development. LRRFIP2 can bind to MyD88 and positively regulate TLR activity as measured by NF-kB activity and cytokine production in macrophages. LPS stimulation also increases LRRFIP2 expression in macrophages. By interacting with Dvl, LRRFIP2 increases the cellular levels of ß-catenin and activate ß-catenin/LEF/TCF-dependent transcriptional activity. A domit negative form of LRRFIP2 suppresses ectopic Wnt signaling in Xenopus embryos and partially inhibits endogenous dorsal axis formation. LRRFIP2 also interacts with Caspase-11 through Flightless-I protein and may be involved in the regulation of proinflammatory caspases by selectively modulating intracellular localization and caspase activity.
|Synthetic peptide (FDQRNYSSLRHSKPTSA (aa151-167)) of LRRFIP2 protein.|
|Equine, Human, Non-human Primate|
|PBS with 0.05% BSA and 0.05% sodium azide|
|HUFI-2, LRR FLII-interacting protein 2, leucine-rich repeat flightless-interacting protein 2|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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