LRRTM2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521097
A suggested positive control is SK-N-SH cell lysate. PA5-21097 can be used with blocking peptide PEP-1211.The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM2 interacts with PSD-95 and regulates the surface expression of AMPA receptors. LRRTM2 also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, suggesting that LRRTM2-Neurexin1 interaction plays a critical role in regulatory excitatory synapse development.
|A 17 amino acid peptide near the carboxy terminus of human LRRTM2.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|O43300, Q8BGA3, D4A7P2|
|leucine-rich repeat neuronal 2 protein; leucine-rich repeat transmembrane neuronal 2 protein; leucine-rich repeat transmembrane neuronal protein 2|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|107065, 26045, 685472|
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