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LSD1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA511306

Catalog No. PIPA511306

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LSD1 is a histone demethylase that specifically demethylates  ft.Lys-4 ft. of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted  ft.Lys-4 ft. of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3  ft.Lys-4 ft. on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate  ft.Lys-9 ft. of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.


PBS with 0.09% sodium azide
O60341, Q6ZQ88
Lysine-specific histone demethylase 1; Amine oxidase flavin containing domain protein 2; BRAF35-HDAC complex protein BHC110; AOF2; KIAA0601; KDM1
400 μL
-20° C, Avoid Freeze/Thaw Cycles
23028, 99982
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
KLH conjugated synthetic peptide between 108-142 amino acids from the N-terminal region of human LSD1
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Human, Mouse
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