LSD1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA511307
This antibody is predicted to react with mouse based on sequence homology.LSD1 is a histone demethylase that specifically demethylates ft.Lys-4 ft. of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted ft.Lys-4 ft. of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 ft.Lys-4 ft. on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate ft.Lys-9 ft. of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.
|PBS with 0.09% sodium azide|
|Lysine-specific histone demethylase 1; Amine oxidase flavin containing domain protein 2; BRAF35-HDAC complex protein BHC110; AOF2; KIAA0601; KDM1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry, Western Blot|
|KLH conjugated synthetic peptide between 457-490 amino acids from the central region of human LSD1|
|Ammonium sulfate precipitation, Size-exclusion - Dialysis|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok