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LXR beta Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520886

Catalog No. PIPA520886


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Description

Description

A suggested positive control is human lung tissue lysate. PA5-20886 can be used with blocking peptide PEP-1000.

LXR-B belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-A, LXR-B forms heterodimers with the retinoic acid receptor RXRalpha, which function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Other studies suggest that genetic variability at the LXR-B gene locus may be a risk factor for Alzheimer’s disease. One hypothesis postulates that LXR may be upstream of ApoE and potentiates the risk associated effects of the epsilon3 allele.
Specifications

Specifications

LXR beta
Polyclonal
Unconjugated
NR1H2
Liquid
NR1H2
A 14 amino acid peptide from near the amino terminus human LXR-B.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P55055, Q60644, Q62755
LXR-b, LXRB, NER, NER-I, RIP15, UNR; LX receptor beta; liver X nuclear receptor beta; liver X receptor beta; liver X receptor-beta; nuclear orphan receptor LXR-beta; nuclear receptor NER; oxysterols receptor LXR-beta; steroid hormone-nuclear receptor NER; ubiquitously-expressed nuclear receptor
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
22260, 58851, 7376
Documents
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