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LYK5 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA513943

Catalog No. PIPA513943

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This antibody is predicted to react with mouse based on sequence homology.

LYK5, also STE20-related Adaptor Protein (STRAD) are members of STE-20 like kinase family that are known to stimulate MAPK pathways by directly activating MAPKKK. LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.
Specifications

Specifications

LYK5
Polyclonal
PBS with 0.09% sodium azide
Q7RTN6, Q3UUJ4
STE20-related adaptor protein; STRAD alpha; Serologically defined breast cancer antigen NY-BR-96; STRAD
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
72149, 92335
Western Blot
Unconjugated
STRADA
Liquid
STRADA
KLH conjugated synthetic peptide between 12-41 amino acids from the N-terminal region of human LYK5
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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