Lyn Mouse, Unlabeled, Clone: 42, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610004
DescriptionLyn is a 56 kDa cytosolic tyrosine kinase that belongs to the Src family of kinases. In addition to Src, this family includes lck, Fgr, Hck, Blk, Yes, fyn, and Yrk kinases. The lyn gene was isolated from a human placenta cDNA library and later found in a variety of cell types. Similar to other members of the Src family of tyrosine kinases, Lyn has been implicated in the regulation of cell signaling mechanisms. Lyn's function has primarily been studied in hematopoietic cells where it is associated with the high-affinity IgE receptor in basophils. It also associates with p120 Ras-GAP in thrombin-stimulated platelets. This association corresponds to an increase in Lyn kinase activity. Lyn is often observed as a doublet of about 56 kDa and 53 kDa. These forms may represent alternative splicing products of lyn mRNA.
|Human Lyn aa. 1-138|
|Canine, Human, Murine, Rat|
|Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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