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Lyn Mouse, Unlabeled, Clone: 42, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610004

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Catalog No. BDB610004


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Description

Description

Lyn is a 56 kDa cytosolic tyrosine kinase that belongs to the Src family of kinases. In addition to Src, this family includes lck, Fgr, Hck, Blk, Yes, fyn, and Yrk kinases. The lyn gene was isolated from a human placenta cDNA library and later found in a variety of cell types. Similar to other members of the Src family of tyrosine kinases, Lyn has been implicated in the regulation of cell signaling mechanisms. Lyn's function has primarily been studied in hematopoietic cells where it is associated with the high-affinity IgE receptor in basophils. It also associates with p120 Ras-GAP in thrombin-stimulated platelets. This association corresponds to an increase in Lyn kinase activity. Lyn is often observed as a doublet of about 56 kDa and 53 kDa. These forms may represent alternative splicing products of lyn mRNA.
Specifications

Specifications

Lyn
42
Unconjugated
Affinity Purified
Human Lyn aa. 1-138
150μg
Cell Biology
Primary
Canine, Human, Murine, Rat
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
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