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Lyn Mouse anti-Human, Mouse, Rat, Clone: LYN-01, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119334

Catalog No. 01-676-090


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Description

Description

Lyn is a Src-family protein tyrosine kinase that is predomitly expressed in hematopoietic cells. It is associated with a number of cell surface receptors including the B cell antigen receptor (BCR) and Fc receptors. Upon their triggering, Lyn phosphorylates subunits of these receptors in a cholesterol-dependent manner, utilizing the plasma membrane lipid raft system. The phosphorylated intracellular domains of the receptors are accessible for cytoplasmic Syk tyrosine kinase, which is activated by Lyn-mediated phosphorylation and which transduces the signal to downstream adaptors. Lyn is abnormally distributed in acute myeloid leukemia cells and seems to be a novel pharmacologic target of this disease.
Specifications

Specifications

LYN
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
P07948, P25911, Q07014
Protein tyrosine kinase p56/p53lyn, JTK8
Mouse
IgG1
100 μg
4° C, do not freeze
Primary
17096, 4067, 81515
Immunocytochemistry, Immunoprecipitation, Western Blot
LYN-01
Unconjugated
LYN
Liquid
LYN
Bacterially expressed recombit fragment of human Lyn. (aa 8-238)
Protein A
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
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