Lyn Mouse anti-Human, Mouse, Rat, Clone: LYN-01, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119334
DescriptionLyn is a Src-family protein tyrosine kinase that is predomitly expressed in hematopoietic cells. It is associated with a number of cell surface receptors including the B cell antigen receptor (BCR) and Fc receptors. Upon their triggering, Lyn phosphorylates subunits of these receptors in a cholesterol-dependent manner, utilizing the plasma membrane lipid raft system. The phosphorylated intracellular domains of the receptors are accessible for cytoplasmic Syk tyrosine kinase, which is activated by Lyn-mediated phosphorylation and which transduces the signal to downstream adaptors. Lyn is abnormally distributed in acute myeloid leukemia cells and seems to be a novel pharmacologic target of this disease.
|PBS with 15mM sodium azide; pH 7.4|
|P07948, P25911, Q07014|
|Protein tyrosine kinase p56/p53lyn, JTK8|
|4° C, do not freeze|
|17096, 4067, 81515|
|Immunocytochemistry, Immunoprecipitation, Western Blot|
|Bacterially expressed recombit fragment of human Lyn. (aa 8-238)|
|Human, Mouse, Rat|
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