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EDG2 Rabbit anti-Human, Mouse, Rat, Xenopus laevis, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA11041

Catalog No. PA11041

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PA1-1041 detects lysophosphatidic acid receptor 1 protein in rat, human, mouse, and Xenopus samples. PA1-1041 has successfully been used in Western blot procedures. By Western blot, this antibody detects an ~42 kDa protein representing lysophosphatidic acid receptor 1 in PC12 and HeLa whole cell lysates as well as mouse and Xenopus liver samples. The PA1-1041 immunogen is a synthetic peptide corresponding to residues L(348) N H T I L A G V H S N D H S V V(364) of human LPA1. The immunizing sequence is completely conserved in human, mouse, rat and bovine. This peptide (Cat. No. PEP-233) is available for use in neutralization and control experiments.

Lysophosphatidic acid receptor 1 (LPA1, EDG2, VZG-1) is a seven transmembrane receptor coupled to G proteins and has high affinity to lypophosphatidic acid (LPA). LPA1 is a member of the EDG-family of receptors which includes LPA1, LPA2 and LPA3. These receptors mediate the serum borne lipid mediator LPA for a variety biological functions. The activation of LPA1 by LPA has shown to stimulate cell spreading and motility, mitogenesis, and various other nervous system activities.

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly



Synthetic peptide corresponding to residues L(348) N H T I L A G V H S N D H S V V(364) of human LPA1.
Antigen affinity chromatography
Human, Mouse, Rat, Xenopus laevis
Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
Q92633, P61793, P61794
LPA1, EDG2, VZG-1, LPA receptor 1, LPA-1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
116744, 14745, 1902
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