Lysozyme Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA140308
PA1-40308 detects Lysozyme from human samples. PA1-40308 has been successfully used in ELISA, immunoprecipitation, and Western blot applications. The PA1-40308 imunogen is human lysozyme.Lysozymes is a 14 kd natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is an antimicrobial protein secreted by polymorphonuclear leukocytes and is widely distributed in secretions such as airway secretions and nasal fluid whereas it is the most effective antimicrobial protein. It is also produced by monocytes, macrophages and epithelial cells, and is one of the anti-microbial agents found in human milk, spleen, lung, kidney, white blood cells, plasma, aliva, and tears. Lysozyme is able to kill bacteria by enzymatic lysis of bacterial cell walls and by a nonenzymatic mechanism. Allthough lysozyme is highly active against many gram-positive bacteria it is ineffective against gram-negative bacteria unless potentiated by certain cofactors (lactoferrin, antibody-complement or hydrogen peroxide-ascorbic acid). Next to its antimicrobial activity lysozyme has many other physiological functions including inactivation of certain viruses, important roles in surveillance of membranes of mammalian cells, immune regulatory activity, anti-inflammatory and antitumor activity.
|ELISA, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|PBS with 0.1% BSA and 0.02% sodium azide|
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