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LOX Rabbit anti-Human, Mouse, Non-human primate, Porcine, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA116989

Catalog No. 01-670-142


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Description

Description

Lysyl oxidase (LOX) is an extracellular enzyme that is critical for the normal biosynthesis of collagens and elastin. LOX is synthesized as a 50kDa precursor, secreted into the extracellular matrix and subsequently proteolytically processed to a 30kDa active enzyme and an 18kDa propeptide. LOX also reverts ras-mediated transformation and its expression is down-regulated in human cancers. Most recently, the lysyl oxidase pro-peptide (LOPP) has been associated with tumor suppression, as it inhibits ras-dependent cellular transformation.

This is a highly glycosylated protein and can exhibit bands at ~32 kDa, ~50kDa and ~58kDa representing the mature (secreted) form, the pro form and the glycosylated forms, respectively.Suggested positive control: MC3T3-E1 lysate.
Specifications

Specifications

LOX
Polyclonal
Unconjugated
LOX
Liquid
LOX
Synthetic peptide made to an internal region of mouse LOX propeptide (residues 78-115). [UniProtNo. P28301]
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Non-human primate, Porcine, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 0.05% sodium azide
P28300, P28301, P45845, P16636
Lysyl oxidase propeptide
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100525278, 16948, 24914, 4015
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