CD204 Goat anti-Human, Polyclonal, Invitrogen
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA184128
This product does not require protein digestion pre-treatment of paraffin embedded sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin embedded sections.CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer ft.s disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a domit negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
|whole serum with 0.1% sodium azide|
|MRS-A, MSR, MSR-A, SR-AI, SR-AII, Scara1, Scvr, MSR1|
|ELISA, Immunohistochemistry (Paraffin), Western Blot|
|Synthetic peptide corresponding to aa 325-342 of human MSR1.|
|4°C or -20°C if preferred|
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