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MAGI3 Sheep anti-Human, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen PA112324

Catalog No. 01-674-108


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Description

Description

PA1-12324 detects a band at ~130 kDa in Western blot applications.

Membrane-associated guanylate kinase with inverted orientation (MAGI3) is a novel, 130 kDa guanylate kinase which is part of a family of multi-PDZ domain containing guanylate kinases. These guanylate kinases are localized to epithelial cell tight junctions. MAGI3 and PTEN/MMAC cooperate to modulate the kinase activity of AKT/protein kinase B (PKB). MAGI3 positions the PTEN/MMAC phosphatase to specific subcellular locations that are involved with the regulation of cell proliferation and survival. MAGI3, as well as other proteins in this family, are made up of an N-terminal guanylate kinase domain, followed by a WW domain, named for two conserved tryptophan residues and first identified as two repeats in mouse YAP65, which is them followed by 5 PDZ domains.
Specifications

Specifications

MAGI3
Polyclonal
Unconjugated
MAGI3
Liquid
MAGI3
Recombit protein corresponding to the guanylate kinase-WW domain of MAGI-3.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 0.08% sodium azide
Q5TCQ9
GKWW domain
Sheep
IgG
250 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
260425
Documents
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